• Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin 

      Karnezi D., Ceron J.J., Theodorou K., Leontides L., Siarkou V.I., Martinez S., Tvarijonaviciute A., Harrus S., Koutinas C.K., Pardali D., Mylonakis M.E. (2016)
      There is currently lack of information on the changes of acute phase proteins (APP) and antioxidant markers and their clinical relevance as treatment response indicators in canine monocytic ehrlichiosis (CME). The objective ...
    • Circulating suPAR associates with severity and in-hospital progression of COVID-19 

      Chalkias A., Skoulakis A., Papagiannakis N., Laou E., Tourlakopoulos K., Pagonis A., Michou A., Ntalarizou N., Mermiri M., Ragias D., Bernal-Morell E., Cebreiros López I., García de Guadiana-Romualdo L., Eugen-Olsen J., Gourgoulianis K., Pantazopoulos I., Chalkias A., Skoulakis A., Laou E., Michou A., Ntalarizou N., Mermiri M., Ragias D., Tourlakopoulos K., Pagonis A., Gourgoulianis K., Pantazopoulos I., Papagiannakis N., Kampolis C., García de Guadiana-Romualdo L., Albaladejo-Otón M.D., Rodríguez Mulero M.D., Galindo Martínez M., Hernández Olivo M., Campos Rodríguez V., Cebreiros López I., Arnaldos Carrillo M., Noguera Velasco J.A., Pascual Figal D.A., Bernal-Morell E., Alcaraz García A., Alcaraz García M.J., Martínez Martínez M., Esteban-Torrella P., Sancho-Rodríguez N., Eugen-Olsen J., for the SPARCOL Investigators (2022)
      Background: COVID-19 disease progression is characterized by hyperinflammation and risk stratification may aid in early aggressive treatment and advanced planning. The aim of this study was to assess whether suPAR and other ...
    • Fibroblast Growth Factor 23 (FGF23) and Klotho Protein in Beta-Thalassemia 

      Stefanopoulos D., Nasiri-Ansari N., Dontas I., Vryonidou A., Galanos A., Psaridi L., Fatouros I.G., Mastorakos G., Papavassiliou A.G., Kassi E., Tournis S. (2020)
      Derangements in phosphate and calcium homeostasis are common in patients with beta-thalassemia. Fibroblast growth factor 23 (FGF23) is among the main hormones regulating phosphate levels, while several studies underline ...
    • Hepcidin as a Sensitive and Treatment-Responsive Acute-Phase Marker in Patients with Bacteremia: A Pilot Study 

      Koukoulas K., Lygoura V., Kartalidis P., Gatselis N.K., Petinaki E., Dalekos G.N., Simos G. (2022)
      Hepcidin regulates iron metabolism by inhibiting intestinal iron absorption and iron release from iron stores. In addition to iron overload, inflammatory conditions also up-regulate hepcidin synthesis, which may serve as ...
    • Hereditary hyperferritinemia cataract syndrome as a cause of childhood hyperferritinemia 

      Tsantoula, F.; Kioumi, A.; Germenis, A. E.; Speletas, M. (2014)
      A 2-year-old female was presented with high levels of serum ferritin (890 ng/mL) in a routine blood test. Clinical and laboratory investigations excluded the presence of iron overload and secondary causes of hyperferritinemia. ...
    • Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children 

      Deli C.K., Fatouros I.G., Paschalis V., Tsiokanos A., Georgakouli K., Zalavras A., Avloniti A., Koutedakis Y., Jamurtas A.Z. (2017)
      Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after ...
    • Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19 

      Dalekos G.N., Stefos A., Georgiadou S., Lygoura V., Michail A., Ntaios G., Samakidou A., Giannoulis G., Gabeta S., Vlychou M., Petinaki E., Leventogiannis K., Giamarellos-Bourboulis E.J., Gatselis N.K. (2021)
      Aims Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may lead to the development of severe respiratory failure. In hospitalized-patients, prompt interruption of the virus-driven inflammatory process ...
    • Non-alcoholic steatohepatitis or autoimmune hepatitis? Sometimes a closer look under the surface is needed 

      Dalekos G.N., Gatselis N.K., Koukoulis G.K. (2020)
      Non-alcoholic fatty liver disease (NAFLD) is nowadays the most common liver disease worldwide. Autoimmune hepatitis (AIH) is a relatively rare disease of the liver characterised by female predominance, circulating ...
    • Oral sucrosomial iron improves exercise capacity and quality of life in heart failure with reduced ejection fraction and iron deficiency: a non-randomized, open-label, proof-of-concept study 

      Karavidas A., Troganis E., Lazaros G., Balta D., Karavidas I.-N., Polyzogopoulou E., Parissis J., Farmakis D. (2021)
      Aims: Oral sucrosomial iron (SI) combines enhanced bioavailability and tolerance compared to conventional oral iron along with similar efficacy compared to intravenous iron in several conditions associated with iron ...
    • Soluble urokinase receptor (SuPAR) in COVID-19-Related AKI 

      Azam T.U., Shadid H.R., Blakely P., O'Hayer P., Berlin H., Pan M., Zhao P., Zhao L., Pennathur S., Pop-Busui R., Altintas I., Tingleff J., Stauning M.A., Andersen O., Adami M.-E., Solomonidi N., Tsilika M., Tober-Lau P., Arnaoutoglou E., Keitel V., Tacke F., Chalkias A., Loosen S.H., Giamarellos-Bourboulis E.J., Eugen-Olsen J., Reiser J., Hayek S.S., Hayek S.S., Blakely P., Berlin H., Azam T.U., Shadid H., Pan M., O'Hayer P., Meloche C., Feroze R., Padalia K.J., Anderson E., Perry D., Bitar A., Kaakati R., Zhao L., Zhao P., Eugen-Olsen J., Altintas I., Tingleff J., Stauning M., Houlind M.B., Lindstrøm M.B., Andersen O., Gamst-Jensen H., Rasmussen L.J.H., Rasmussen C., Nehlin J.O., Kallemose T., Parvaiz I., Adami M.-E., Solomonidi N., Tsilika M., Saridaki M., Lekakis V., Loosen S., Luedde T., Keitel V., Arnaoutoglou E., Pantazopoulos I., Laou E., Kolonia K., Skoulakis A., Tacke F., Tober-Lau P., Mohr R., Kurth F., Sander L.E., Jochum C., International Study of Inflammation in COVID-19 (2020)
      Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, ...
    • Α 57-Year-Old Woman With ARDS, Cachexia, and a 2-Month Fever 

      Tsolaki V., Manoulakas E., Makris D., Boutlas S., Daniil Z., Gourgoulianis K.I., Zakynthinos E. (2019)
      Case Presentation: A 57-year-old homemaker and rural inhabitant of Central Greece (ex-smoker, 25 pack-years), was admitted to the ICU because of acute hypoxemic respiratory failure with diffuse bilateral alveolar infiltrates. ...